| 2026-05-16 | UFC Fight Night: Allen vs. Costa | Featherweight | Arnold Allen def. Melquizael Costa | Decision (unanimous) (50–45, 50–45, 49–46) | 5 | 5:00 |
| 2026-02-21 | UFC Fight Night: Strickland vs. Hernandez | Featherweight | Melquizael Costa def. Dan Ige | TKO (spinning back kick and punches) | 1 | 4:56 |
| 2025-12-13 | UFC on ESPN: Royval vs. Kape | Featherweight | Melquizael Costa def. Morgan Charrière | KO (head kick) | 1 | 1:14 |
| 2025-05-17 | UFC Fight Night: Burns vs. Morales | Featherweight | Melquizael Costa def. Julian Erosa | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2025-03-29 | UFC on ESPN: Moreno vs. Erceg | Featherweight | Melquizael Costa def. Christian Rodriguez | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2025-02-22 | UFC Fight Night: Cejudo vs. Song | Featherweight | Melquizael Costa def. Andre Fili | Submission (guillotine choke) | 1 | 4:30 |
| 2024-06-15 | UFC on ESPN: Perez vs. Taira | Featherweight | Melquizael Costa def. Shayilan Nuerdanbieke | Submission (face crank) | 3 | 1:50 |
| 2023-12-09 | UFC Fight Night: Song vs. Gutiérrez | Lightweight | Steve Garcia def. Melquizael Costa | KO (elbows) | 2 | 1:01 |
| 2023-07-15 | UFC on ESPN: Holm vs. Bueno Silva | Featherweight | Melquizael Costa def. Austin Lingo | Decision (unanimous) (30–26, 30–27, 30–27) | 3 | 5:00 |
| 2023-01-21 | UFC 283: Teixeira vs. Hill | Lightweight | Thiago Moisés def. Melquizael Costa | Submission (face crank) | 2 | 4:05 |