| 2013-10-09 | UFC Fight Night: Maia vs. Shields | Catchweight | Thiago Silva def. Matt Hamill | Decision (unanimous) (30–27, 30–27, 29–27) | 3 | 5:00 |
| 2012-09-22 | UFC 152: Jones vs. Belfort | Light Heavyweight | Matt Hamill def. Roger Hollett | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |
| 2011-08-06 | UFC 133: Evans vs. Ortiz | Light Heavyweight | Alexander Gustafsson def. Matt Hamill | TKO (punches and elbows) | 2 | 3:34 |
| 2011-05-28 | UFC 130: Rampage vs. Hamill | Light Heavyweight | Quinton Jackson def. Matt Hamill | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2010-10-23 | UFC 121: Lesnar vs. Velasquez | Light Heavyweight | Matt Hamill def. Tito Ortiz | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2010-06-19 | The Ultimate Fighter: Team Liddell vs. Team Ortiz Finale | Light Heavyweight | Matt Hamill def. Keith Jardine | Decision (majority) (29–27, 29–27, 28–28) | 3 | 5:00 |
| 2009-12-05 | The Ultimate Fighter: Heavyweights Finale | Light Heavyweight | Matt Hamill def. Jon Jones | DQ (illegal downwards elbows) | 1 | 4:14 |
| 2009-03-07 | UFC 96: Jackson vs. Jardine | Light Heavyweight | Matt Hamill def. Mark Muñoz | KO (head kick) | 1 | 3:53 |
| 2008-12-27 | UFC 92: The Ultimate 2008 | Light Heavyweight | Matt Hamill def. Reese Andy | TKO (punches) | 2 | 2:19 |
| 2008-09-06 | UFC 88: Breakthrough | Light Heavyweight | Rich Franklin def. Matt Hamill | TKO (body kick and punches) | 3 | 0:39 |
| 2008-04-02 | UFC Fight Night: Florian vs. Lauzon | Light Heavyweight | Matt Hamill def. Tim Boetsch | TKO (punches) | 2 | 1:25 |
| 2007-09-08 | UFC 75: Champion vs. Champion | Light Heavyweight | Michael Bisping def. Matt Hamill | Decision (split) (29–28, 27–30, 29–28) | 3 | 5:00 |
| 2007-03-03 | UFC 68: The Uprising | Light Heavyweight | Matt Hamill def. Rex Holman | TKO (punches) | 1 | 4:00 |
| 2006-10-10 | UFC Fight Night 6.5 | Light Heavyweight | Matt Hamill def. Seth Petruzelli | Decision (unanimous) (29–28, 30–27, 29–28) | 3 | 5:00 |
| 2006-06-24 | The Ultimate Fighter: Team Ortiz vs. Team Shamrock Finale | Light Heavyweight | Matt Hamill def. Jesse Forbes | TKO (punches) | 1 | 4:47 |