| 2018-08-04 | UFC 227: Dillashaw vs. Garbrandt 2 | Flyweight | Henry Cejudo def. Demetrious Johnson title | Decision (split) (48–47, 47–48, 48–47) | 5 | 5:00 |
| 2017-10-07 | UFC 216: Ferguson vs. Lee | Flyweight | Demetrious Johnson def. Ray Borg title | Submission (armbar) | 5 | 3:15 |
| 2017-04-15 | UFC on Fox: Johnson vs. Reis | Flyweight | Demetrious Johnson def. Wilson Reis title | Submission (armbar) | 3 | 4:49 |
| 2016-12-03 | The Ultimate Fighter: Tournament of Champions Finale | Flyweight | Demetrious Johnson def. Tim Elliott title | Decision (unanimous) (49–46, 49–46, 49–45) | 5 | 5:00 |
| 2016-04-23 | UFC 197: Jones vs. Saint Preux | Flyweight | Demetrious Johnson def. Henry Cejudo title | TKO (knees and punches) | 1 | 2:49 |
| 2015-09-05 | UFC 191: Johnson vs. Dodson 2 | Flyweight | Demetrious Johnson def. John Dodson title | Decision (unanimous) (49–46, 49–46, 50–45) | 5 | 5:00 |
| 2015-04-25 | UFC 186: Johnson vs. Horiguchi | Flyweight | Demetrious Johnson def. Kyoji Horiguchi title | Submission (armbar) | 5 | 4:59 |
| 2014-09-27 | UFC 178: Johnson vs. Cariaso | Flyweight | Demetrious Johnson def. Chris Cariaso title | Submission (kimura) | 2 | 2:29 |
| 2014-06-14 | UFC 174: Johnson vs. Bagautinov | Flyweight | Demetrious Johnson def. Ali Bagautinov title | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2013-12-14 | UFC on Fox: Johnson vs. Benavidez 2 | Flyweight | Demetrious Johnson def. Joseph Benavidez title | KO (punch) | 1 | 2:08 |
| 2013-07-27 | UFC on Fox: Johnson vs. Moraga | Flyweight | Demetrious Johnson def. John Moraga title | Submission (armbar) | 5 | 3:43 |
| 2013-01-26 | UFC on Fox: Johnson vs. Dodson | Flyweight | Demetrious Johnson def. John Dodson title | Decision (unanimous) (48–47, 49–46, 48–47) | 5 | 5:00 |
| 2012-09-22 | UFC 152: Jones vs. Belfort | Flyweight | Demetrious Johnson def. Joseph Benavidez | Decision (split) (48–47, 47–48, 49–46) | 5 | 5:00 |
| 2012-06-08 | UFC on FX: Johnson vs. McCall 2 | Flyweight | Demetrious Johnson def. Ian McCall | Decision (unanimous) (29–28, 30–27, 29–28) | 3 | 5:00 |
| 2012-03-03 | UFC on FX: Alves vs. Kampmann | Flyweight | Demetrious Johnson vs. Ian McCall | Draw (majority) (28–28, 29–29, 29–28) | 3 | 5:00 |
| 2011-10-01 | UFC Live: Cruz vs. Johnson | Bantamweight | Dominick Cruz def. Demetrious Johnson title | Decision (unanimous) (50–45, 49–46, 50–45) | 5 | 5:00 |
| 2011-05-28 | UFC 130: Rampage vs. Hamill | Bantamweight | Demetrious Johnson def. Miguel Torres | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2011-02-05 | UFC 126: Silva vs. Belfort | Bantamweight | Demetrious Johnson def. Norifumi Yamamoto | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |