| 2010-06-12 | UFC 115: Liddell vs. Franklin | Middleweight | Mario Miranda def. David Loiseau | TKO (punches) | 2 | 4:07 |
| 2009-04-18 | UFC 97: Redemption | Middleweight | Ed Herman def. David Loiseau | Decision (unanimous) (30–26, 30–27, 30–27) | 3 | 5:00 |
| 2006-09-23 | UFC 63: Hughes vs. Penn | Middleweight | Mike Swick def. David Loiseau | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2006-03-04 | UFC 58: USA vs. Canada | Middleweight | Rich Franklin def. David Loiseau title | Decision (unanimous) (50–43, 50–42, 50–42) | 5 | 5:00 |
| 2005-10-03 | UFC Ultimate Fight Night 2 | Middleweight | David Loiseau def. Evan Tanner | TKO (doctor stoppage) | 2 | 4:15 |
| 2005-06-04 | UFC 53: Heavy Hitters | Middleweight | David Loiseau def. Charles McCarthy | TKO (spinning back kick and flying knee) | 2 | 2:10 |
| 2005-02-05 | UFC 51: Super Saturday | Middleweight | David Loiseau def. Gideon Ray | TKO (doctor stoppage) | 1 | 5:00 |
| 2003-09-26 | UFC 44: Undisputed | Middleweight | Jorge Rivera def. David Loiseau | Decision (unanimous) (29–28, 29–27, 29–28) | 3 | 5:00 |
| 2003-04-25 | UFC 42: Sudden Impact | Middleweight | David Loiseau def. Mark Weir | KO (punches) | 1 | 3:55 |