| 2015-05-16 | UFC Fight Night: Edgar vs. Faber | Middleweight | Gegard Mousasi def. Costas Philippou | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-05-10 | UFC Fight Night: Brown vs. Silva | Middleweight | Costas Philippou def. Lorenz Larkin | KO (punch) | 1 | 3:47 |
| 2014-01-15 | UFC Fight Night: Rockhold vs. Philippou | Middleweight | Luke Rockhold def. Costas Philippou | TKO (body kick) | 1 | 2:31 |
| 2013-09-21 | UFC 165: Jones vs. Gustafsson | Middleweight | Francis Carmont def. Costas Philippou | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2012-12-29 | UFC 155: dos Santos vs. Velasquez 2 | Middleweight | Costas Philippou def. Tim Boetsch | TKO (punches) | 3 | 2:11 |
| 2012-07-07 | UFC 148: Silva vs. Sonnen II | Middleweight | Costas Philippou def. Riki Fukuda | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2012-03-03 | UFC on FX: Alves vs. Kampmann | Middleweight | Costas Philippou def. Court McGee | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2011-12-10 | UFC 140: Jones vs. Machida | Middleweight | Costas Philippou def. Jared Hamman | KO (punches) | 1 | 3:11 |
| 2011-08-06 | UFC 133: Evans vs. Ortiz | Middleweight | Costas Philippou def. Jorge Rivera | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2011-03-19 | UFC 128: Shogun vs. Jones | Catchweight | Nick Catone def. Costas Philippou | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |